The main symptoms of neonatal hypocalcaemia are agitation, tremors, lethargy, seizures, changes in muscle tone, stridor or prolongation of the QTc interval (>0.4 ms).
They must be assessed as early warning signs of disorders like hypocalcaemia and VDD. Tremors are the most frequent paroxysmal manifestations in the neonatal period, and hypotonia and lethargy are nonspecific symptoms found in neonatal metabolic disorders. Both mothers were treated successfully with calcifediol supplementation. The mother had serum levels of vitamin D of 4.2 ng/mL, of PTH of 57.9 pg/mL, of total calcium of 8 mg/dL and of phosphorus of 2.5 mg/dL.īoth mothers resided in Teruel (latitude, 40.25°) and had a skin phototype of 1–2 in the Fitzpatrick scale, a low level of physical activity (took some walks each week) and a body mass index under 30 kg/m 2, and neither was taking vitamin D. Calcium gluconate 10% was administered to the patient by the oral route at a dose of 2 mL/kg/day, which improved the clinical manifestations. He had serum levels of ionized calcium of 3.27 mg/dL, total calcium of 8.2 mg/dL and vitamin D of 7.1 ng/mL. The boy was born in February in an uncomplicated delivery at 40 weeks of gestation, with a birth weight of 3180 g. The mother was of Arabic ancestry with no exposure to sunlight.
Testing in the mother found levels of vitamin D of 13 ng/mL and of parathyroid hormone (PTH) of 82.8 pg/mL (15–65 pg/mL).Ĭase 2: newborn boy that exhibited hypotonia and lethargy at 48 h post birth. The infant was given calcium gluconate 10% orally at a dose of 2 mL/kg/day, which improved the clinical manifestations. Testing found serum levels of ionized calcium of 4.2 mg/dL, total calcium of 8.1 mg/dL and vitamin D of 14 ng/mL. The patient was born in March at 38 weeks of gestation with a birth weight 3590 g in an uncomplicated vaginal delivery. The mother was of European ascent exposed to sunlight less than 30 min a day. We describe our experience with 2 cases of neonatal early-onset hypocalcaemia (NEOH) associated with neonatal and maternal VDD.Ĭase 1: newborn girl that developed pathologic tremors at 40 h post birth. Vitamin D deficiency (VDD) has been described as a cause of neonatal late-onset hypocalcaemia (NLOH). Neonatal hypocalcaemia is a common and potentially severe metabolic disorder of variable aetiology.
0 kommentar(er)
